The ATAGC histology regression equations and Reference Standard classification for kidney transplant biopsies
The Alberta Transplant Applied Genomics Centre (ATAGC) addresses unmet needs in medicine in terms of understanding disease states, including diagnosis, activity, stage, prognosis, and guidance for therapy. Currently, microscope-based diagnostic labels are imperfect measures for assessing disease. Existing systems are arbitrary, subjective, and lack quantification. Consequently, there are inaccuracies and delays in treatment, and impediments to development of new drugs.
The current “gold standard” to biopsy based diagnosis of the true organ disease process has up to 50% error rates:
There are four central elements to our research approach: